Behandelmogelijkheden
Gemetastaseerd
Carboplatin / paclitaxel: Carboplatin AUC 5, dag 1 en Paclitaxel (80 mg/m2) dag 1, 8, 15 elke 28 dagen (InterAAct, Rao 2020)
Alternatief:
- capecitabine 1000 tot 1250 mg/m2 2 dd gedurende 14/21 dagen.
Literatuur
- Glynne-Jones R, Meadows H, Wan S, Gollins S, Leslie M, Levine E, et al. EXTRAa multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancer. Int J Radiat Oncol Biol Phys. 2008;72(1):119-26.
- Rao S, Sclafani F, Eng C, Adams RA, Guren MG, Sebag-Montefiore D, et al. International Rare Cancers Initiative Multicenter Randomized Phase II Trial of Cisplatin and Fluorouracil Versus Carboplatin and Paclitaxel in Advanced Anal Cancer: InterAAct. J Clin Oncol. 2020;38(22):2510-8.