Literatuur

  1. Annals of Oncology 29 (Supplement 4): iv51-iv67, 2018 ESMO guidelines STS.
  2. Santoro A, Tursz T, Mouridsen H, et al. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol 1995; 13:1537.
  3. Seddon B, Strauss SJ, et al. Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial. Lancet Oncol 2017 Oct;18(10):1397-1410.
  4. van der Graaf WT, Blay JY, Chawla SP, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012; 379:1879.
  5. Demetri GD, von Mehren M, Jones RL, et al. Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial. J Clin Oncol 2016; 34:786.
  6. Schöffski P, Chawla S, Maki RG, et al. Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial. Lancet 2016; 387:1629.
  7. Mir O, Domont J, Cioffi A, Bonvalot S, Boulet B, Le Pechoux C, Terrier P,Spielmann M, Le Cesne A. Feasibility of metronomic oral cyclophosphamide plus prednisolone in elderly patients with inoperable or metastatic soft tissue sarcoma. Eur J Cancer. 2011 Mar;47(4):515-9. doi: 10.1016/j.ejca.2010.11.025. Epub 2011 Jan 19.
  8. Penel N, Bui BN, et al. Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol. 2008 Nov 10;26(32):5269-74.
  9. Joensuu H, Eriksson M, et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA. 2012 Mar 28;307(12):1265-72.
  10. Casali PG, Zalcberg J, et al. Ten-Year Progression-Free and Overall Survival in Patients With Unresectable or Metastatic GI Stromal Tumors: Long-Term Analysis of the European Organisation for Research and Treatment of Cancer, Italian Sarcoma Group, and Australasian Gastrointestinal Trials Group Intergroup Phase III Randomized Trial on Imatinib at Two Dose Levels. J Clin Oncol. 2017 May 20;35(15):1713-1720.
  11. Demetri GD, van Oosterom AT, Garrett CR et al (2006) Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368:1329–1338.
  12. Demetri GD, Reichardt P, et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013 Jan 26;381(9863):295-302.
  13. Kang YK, Ryu MH, et al. Resumption of imatinib to control metastatic or unresectable gastrointestinal stromal tumours after failure of imatinib and sunitinib (RIGHT): a randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 2013 Nov;14(12):1175-82.
  14. Thomas D, Henshaw R, Skubitz K, et al. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol 2010; 11:275.
  15. Uqurel S, Mentzel T. Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up. Clin Cancer Res. 2014 Jan 15;20(2):499-510.
  16. Cassier PA, Gelderblom H, et al. Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. Cancer. 2012 Mar 15;118(6):1649-55.
  17. Stacchiotti S, Longhi A, et al. Phase II study of imatinib in advanced chordoma. J Clin Oncol. 2012 Mar 20;30(9):914-20.
  18. Cianfrocca M, Lee S, et al. Randomized trial of paclitaxel versus pegylated liposomal doxorubicin for advanced human immunodeficiency virus-associated Kaposi sarcoma: evidence of symptom palliation from chemotherapy. Cancer. 2010 Aug 15;116(16):3969-77.
  19. Marina NM, Smeland S, Bielack SS, et al. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol 2016; 17:1396.
  20. Bielack SS, Smeland S, Whelan JS, et al. Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial. J Clin Oncol 2015; 33:2279.
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  22. Grier HE, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348:694.
  23. Arndt CA, Stoner JA, Hawkins DS, et al. Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803. J Clin Oncol 2009; 27:5182.
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Informatie voor zorgprofessionals Medische Oncologie Tumortypes Sarcomen

Sarcomen

Het wordt sterk aanbevolen om patiënten met een sarcoom te behandelen in of in overleg met een Sarcomen Expertisecentrum. Het behandelplan dient te worden vastgesteld in een Multidisciplinair Sarcomen Overleg. lees meer

Sarcomen

Het wordt sterk aanbevolen om patiënten met een sarcoom te behandelen in of in overleg met een Sarcomen Expertisecentrum. Het behandelplan dient te worden vastgesteld in een Multidisciplinair Sarcomen Overleg.

U wordt laagdrempelig uitgenodigd patiënten in het MDO te bespreken of met ons te overleggen.

Telefonisch: 024-3618800, E-mail: suzanne.kaal@radboudumc.nl of ingrid.desar@radboudumc.nl

Literatuur

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Tumorsoorten

Weke delen sarcomen

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Gastro intestinale stroma tumoren (GIST)

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Botsarcomen

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Desmoid fibromatose

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Desmoid fibromatose

Desmoid fibromatose

In principe afwachtend beleid (in verband met kans op spontane regressie, stabilisatie).

Keuze medicamenteuze therapie is afhankelijk van klachten, mate progressie, anatomische lokalisatie. Opties: 

  1. Tamoxifen 2 dd 40 mg + meloxicam 1 dd 15 mg.
  2. Sorafenib 1 dd 400 mg po.
  3. Liposomaal doxorubicine (Caelyx) 40 mg/m2 IV q 4 weken.

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Studies

DO2.22.01

Solide tumoren, fase I, MET, MET kinase inhibitor

SADDRIN

Sarcomen, fase I, radiotherapie, DDR remmers

STRASS-2

DDLPS of LMS, fase III, neoadjuvante chemotherapie

Debio 0123

Solide tumoren, fase I, 2e lijn, selectieve WEE1 remmer (+carboplatine)

DRUP

Solide tumoren, ‘actionable’ moleculaire target

DRUG access

Solide tumoren, EMA geregistreerde middelen